BindGene

Christopher R Lockwood

My PhD thesis on the evolution of gene regulation

In July 2008, I was formally awarded the PhD qualification by the University of Manchester, England. The actual thesis title is "Can Gains and Losses of Transcription Factor Binding Sites be Related to What Occurs Elsewhere in the Regulatory Region?". Here is the PhD thesis (all in PDF format):

Abstract

List of contents, etc
Chapter 1: Introduction and Literature Review
Chapter 2: Examination of Known Real Sites (from the TransFac Database) - first half
Chapter 2: Examination of Known Real Sites (from the TransFac Database) - second half
Chapter 3: Examination of Known Real Sites (from ChIP-chip data)
Chapter 4: Sequence Changes Expected to be Associated with Gains and Losses of TFBSs
Chapter 5: Phylogenetic Trees: Distinguishing Gains from Losses of TFBSs
Chapter 6: Summary and Discussion
Bibliography
Appendices